Handy Manny is set in the fictional town of Sheetrock Hills where the titular character, Manny, owns a repair shop along with his anthropomorphic talking tools. It is unknown exactly where this town is located, but there are a multitude of Spanish speaking residents within it and the town is surrounded by tropical ocean water (as seen in the introduction). Most 30-minute episodes contain two stories. They typically begin with Manny and the tools interacting in Manny’s repair shop. While there, someone, usually needing something repaired or assembled, calls Manny, who answers, “Hola, Handy Manny’s Repair Shop. You break it. . . ” and then the Tools shout “We fix it!” After hearing who needs help where, Manny and the Tools sing “Hop Up, Jump In” while the Tools hop into his tool box. In each episode when Manny and the Tools leave for the repair, they see Mr. Lopart with his pet cat Fluffy in front of his candy store. Mr. Lopart would try to do something on his own without any prior experience. Manny offers him to help but Mr. Lopart says that he doesn’t need any help, after Manny and the Tools leave the item Mr. Lopart was building would malfunction and cause a mess. Once Manny and the tools arrive at the repair site, they collaborate on the best way to fix the broken item. Manny then goes to Kelly’s hardware store where she always has the item that they need. Once they have the items needed for the repair, they go back to the work-site and sing “We Work Together” while performing the repairs.
In each episode, the item is fixed.